QuickView for Conjugated Estrogens (compound)

Summary
General Info

PubChem Substance

Name:	Estrogens, Conjugated (USP)
PubChem Substance ID:	17398021
Description:	A pharmaceutical preparation containing a mixture of water-soluble, conjugated estrogens derived wholly or in part from URINE of pregnant mares or synthetically from ESTRONE and EQUILIN. It contains a sodium-salt mixture of estrone sulfate (52-62%) and equilin sulfate (22-30%) with a total of the two between 80-88%. Other concomitant conjugates include 17-alpha-dihydroequilin, 17-alpha-estradiol, and 17-beta-dihydroequilin. The potency of the preparation is expressed in terms of an equivalent quantity of sodium estrone sulfate.
Synonyms:	Estrogens, Conjugated; D04070; Premarin; Premarin (TN); Estrogens, conjugated (JAN/USP); 12126-59-9

DrugBank

Identification

Name:	Estrogens, Conjugated (USP)
Name (isomeric):	DB00286
Drug Type:	small molecule
Description:	A pharmaceutical preparation containing a mixture of water-soluble, conjugated estrogens derived wholly or in part from URINE of pregnant mares or synthetically from ESTRONE and EQUILIN. It contains a sodium-salt mixture of estrone sulfate (52-62%) and equilin sulfate (22-30%) with a total of the two between 80-88%. Other concomitant conjugates include 17-alpha-dihydroequilin, 17-alpha-estradiol, and 17-beta-dihydroequilin. The potency of the preparation is expressed in terms of an equivalent quantity of sodium estrone sulfate.
Synonyms:	Oestrone Sulphate; Estrone-sulfate; Estrone Sulfate Sodium; Estrone Sodium Sulfate; Estrogens; Sodium Estrone Sulfate; Estrone Hydrogen Sulfate; Estrone Sulphate; Estrone Sulfate; Estrone Estrone Hydrogen Sulfate
Brand:	Par Estro, Premarin tabs, Premarin Vaginal, Premarin, Prempro, Morestin, Hyhorin, Conestoral, Prempro/Premphase, Evex
Brand name mixture:	Prempro(conjugated estrogens + medroxyprogesteron)
Category:	Estrogens
CAS number:	438-67-5

Pharmacology

Indication:	For the treatment of moderate to severe vasomotor symptoms associated with the menopause, atrophic vaginitis, osteoporosis, hypoestrogenism due to hypogonadism, castration, primary ovarian failure, breast cancer (for palliation only), and Advanced androgen-dependent carcinoma of the prostate (for palliation only)
Pharmacology:	Conjugated estrogens, a mixture of the water soluble salts of sulfate esters from estrone, equilin, 17 α-dihydroequilin, and other related steroids, may be derived from pregnant equine urine or yam and soy plants. Estrogens are important in the development and maintenance of the female reproductive system and secondary sex characteristics. Th... show more » Conjugated estrogens, a mixture of the water soluble salts of sulfate esters from estrone, equilin, 17 α-dihydroequilin, and other related steroids, may be derived from pregnant equine urine or yam and soy plants. Estrogens are important in the development and maintenance of the female reproductive system and secondary sex characteristics. They promote growth and development of the vagina, uterus, and fallopian tubes, and enlargement of the breasts. Indirectly, they contribute to the shaping of the skeleton, maintenance of tone and elasticity of urogenital structures, changes in the epiphyses of the long bones that allow for the pubertal growth spurt and its termination, growth of axillary and pubic hair, and pigmentation of the nipples and genitals. Decline of estrogenic activity at the end of the menstrual cycle can bring on menstruation, although the cessation of progesterone secretion is the most important factor in the mature ovulatory cycle. However, in the preovulatory or nonovulatory cycle, estrogen is the primary determinant in the onset of menstruation. Estrogens also affect the release of pituitary gonadotropins. The pharmacologic effects of conjugated estrogens are similar to those of endogenous estrogens. show less «
Mechanism of Action:	Estrogens enter the cells of responsive tissues (e.g., female organs, breasts, hypothalamus, pituitary) where they interact with a protein receptor, subsequently increasing the rate of synthesis of DNA, RNA, and some proteins. Estrogens decrease the secretion of gonadotropin-releasing hormone by the hypothalamus, reducing the secretion of follicle-... show more » Estrogens enter the cells of responsive tissues (e.g., female organs, breasts, hypothalamus, pituitary) where they interact with a protein receptor, subsequently increasing the rate of synthesis of DNA, RNA, and some proteins. Estrogens decrease the secretion of gonadotropin-releasing hormone by the hypothalamus, reducing the secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. show less «
Absorption:	Well absorbed
Protein binding:	90% bound to plasma proteins
Biotransformation:	Hepatic
Route of elimination:	Estradiol, estrone, and estriol are excreted in the urine, along with glucuronide and sulfate conjugates. Exogenous estrogens are metabolized in the same manner as endogenous estrogens.
Half Life:	7.4 hours
Toxicity:	Nausea and vomiting
Affected organisms:	Humans and other mammals

Interactions

Food interaction:

Take with food to reduce nausea.

Avoid alcohol.

Avoid excessive quantities of coffee or tea (Caffeine).

Drug interaction:

Prednisone	The estrogenic agent may increase the effect of corticosteroid, prednisone.
Methohexital	The enzyme inducer, methohexital, decreases the effect of the hormone agent, conjugated estrogens.
Prednisolone	The estrogenic agent may increase the effect of the corticosteroid, prednisolone.
Phenobarbital	The enzyme inducer, phenobarbital, decreases the effect of the hormone agent, conjugated estrogens.
Heptabarbital	The enzyme inducer, heptabarbital, decreases the effect of the hormone agent, conjugated estrogens.

Prednisone	The estrogenic agent may increase the effect of corticosteroid, prednisone.
Methohexital	The enzyme inducer, methohexital, decreases the effect of the hormone agent, conjugated estrogens.
Prednisolone	The estrogenic agent may increase the effect of the corticosteroid, prednisolone.
Phenobarbital	The enzyme inducer, phenobarbital, decreases the effect of the hormone agent, conjugated estrogens.
Heptabarbital	The enzyme inducer, heptabarbital, decreases the effect of the hormone agent, conjugated estrogens.
Hexobarbital	The enzyme inducer, hexobarbital, decreases the effect of the hormone agent, conjugated estrogens.
Methylphenobarbital	The enzyme inducer, methylphenobarbital, decreases the effect of the hormone agent, conjugated estrogens.
Griseofulvin	The enzyme inducer, griseofulvin, decreases the effect of the hormone agent, conjugated estrogens.
Pentobarbital	The enzyme inducer, pentobarbital, decreases the effect of the hormone agent, conjugated estrogens.
Fosphenytoin	The enzyme inducer, fosphenytoin, decreases the effect of the hormone agent, conjugated estrogens.
Raloxifene	Association not recommended
Phenytoin	The enzyme inducer, phenytoin, decreases the effect of the hormone agent, conjugated estrogens.
Butabarbital	The enzyme inducer, butabarbital, decreases the effect of the hormone agent, conjugated estrogens.
Butethal	The enzyme inducer, butethal, decreases the effect of the hormone agent, conjugated estrogens.
Aprobarbital	The enzyme inducer, aprobarbital, decreases the effect of the hormone agent, conjugated estrogens.
Ursodeoxycholic acid	Estrogens decreases the effect of ursodiol
Ethotoin	The enzyme inducer, ethotoin, decreases the effect of the hormone agent, conjugated estrogens.
Butalbital	The enzyme inducer, butalbital, decreases the effect of the hormone agent, conjugated estrogens.
Tipranavir	Conjugated estrogens may increase the adverse dermatological effects (i.e. skin rash) of Tipranavir. Tipranavir may decrease the serum concentration Conjugated estrogens. Monitor for estrogen deficiency during concomitant therapy.
Amobarbital	The enzyme inducer, amobarbital, decreases the effect of the hormone agent, conjugated estrogens.
Talbutal	The enzyme inducer, talbutal, decreases the effect of the hormone agent, conjugated estrogens.
Secobarbital	The enzyme inducer, secobarbital, decreases the effect of the hormone agent, conjugated estrogens.
Mephenytoin	The enzyme inducer, mephenytoin, decreases the effect of the hormone agent, conjugated estrogens.
Primidone	The enzyme inducer, primidone, decreases the effect of the hormone agent, conjugated estrogens.